
The One You Want to Protect Your Cat
NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution) is protection for cats. It’s the first and only broad-spectrum parasite protection specifically designed for cats that kills fleas and ticks, prevents heartworm disease, and treats and controls roundworms, hookworms, and tapeworms. All cats, indoor and outdoor, need parasite protection, and NexGard COMBO topical solution is specifically formulated to give cats the protection they need. See How NexGard COMBO Topical Solution Compares to the Competition.

One-And-Done Monthly Solution
Kills fleas and ticks, prevents heartworm disease, and treats and controls roundworms, hookworms, and tapeworms.

Easy to Apply
Comes in a convenient applicator that makes monthly parasite protection easy for you and your cat.

Safe for Kittens
Safe for kittens 8 weeks of age and older, weighing 1.8 lbs or more.
Fights Internal and External Parasites
Indoor and outdoor cats need protection from both internal and external parasites. That’s why there’s NexGard COMBO topical solution: the first and only broad-spectrum solution for cats that kills fleas and ticks, prevents heartworm disease, and treats and controls roundworms, hookworms, and tapeworms.
Formulated Specifically for Cats
One of the active ingredients in NexGard COMBO topical solution, esafoxolaner, was formulated specifically for use in cats. NexGard COMBO topical solution is the only product on the market to offer this formulation, and the only product on the market to offer broad-spectrum protection that kills tapeworms.

All Cats Need Parasite Protection
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NexGard COMBO topical solution is safe for use in kittens as young as 8 weeks, weighing 1.8 lbs or more.
Compare to Other Products
NexGard® COMBO | REVOLUTION® PLUS1 | BRAVECTO® PLUS2 | ADVANTAGE MULTI3 | |
---|---|---|---|---|
Kills Adult Fleas | applicable | applicable | applicable | applicable |
Kills Ticks | Black-legged tick, Lone star tick |
Black-legged tick, Asian longhorned tick, American dog tick |
Black-legged tick, Gulf coast tick, American dog tick |
|
Prevents heartworm disease | applicable | applicable | applicable | applicable |
Treats & Controls Roundworms (Toxocara cati) |
applicable | applicable | applicable | applicable |
Treats & Controls Hookworms (Anclyostoma tubaeforme) |
applicable | applicable | applicable | applicable |
Treats & Controls Hookworms (Ancylostoma braziliense) |
applicable | |||
Treats & Controls Tapeworms (Dipylidium caninum) |
applicable | |||
Safe for use in kittens <6 months of age |
8 weeks of age or older, weighing 1.8 lbs or greater |
8 weeks of age or older, weighing 2.8 lbs or greater |
6 months of age or older, weighing 2.6 lbs or greater |
9 weeks of age or older, weighing 2 lbs or greater |
Find Protection for Your Dog or Cat
Learn more about our products. Your vet can help you determine the right protection for your pet.

NexGard PLUS Chews: One-And-Done Monthly Protection for Dogs
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KILLS fleas & ticks
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PREVENTS heartworm disease
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TREATS and controls roundworms and hookworms
IMPORTANT SAFETY INFORMATION
NexGard® PLUS (afoxolaner, moxidectin, and pyrantel chewable tablets) is safe for puppies at 8 weeks, weighing 4 pounds or more. The most frequently reported adverse reactions include diarrhea, vomiting, lethargy, and itching. Use with caution in dogs with a history of seizures or neurologic disorders. Dogs should be tested for existing heartworm infection prior to starting a preventive. For more information, click here for full prescribing information.

NexGard COMBO Topical Solution: Monthly Protection for Cats
-
KILLS fleas & ticks
-
PREVENTS heartworm disease
-
PREVENTS heartworm disease
IMPORTANT SAFETY INFORMATION
NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution) is for topical use only in cats. Safe for use in cats and kittens 8 weeks of age or older, weighing 1.8 lbs or more. Use with caution in cats with a history of seizures or neurologic disorders. The most frequently reported adverse reactions include vomiting, application site reactions, lethargy, and anorexia. If ingested, hypersalivation may occur. Avoid direct contact with application site until visibly dry. For more information, click here for full prescribing information.

NexGard Chews: Monthly Flea & Tick Protection for Dogs
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KILLS fleas & ticks
-
PREVENTS Lyme disease infections by killing black-legged ticks
IMPORTANT SAFETY INFORMATION
NexGard® (afoxolaner) is for use in dogs only. Safe for use in puppies 8 weeks of age or older, weighing 4 pounds or more. The most frequently reported adverse reactions include vomiting, itching, lethargy, diarrhea, and lack of appetite. The safe use of NexGard in pregnant, breeding, or lactating dogs has not been evaluated. Use with caution in dogs with a history of seizures or neurologic disorders. For more information, click here for full prescribing information.

NexGard PLUS Chews: One-And-Done Monthly Protection for Dogs
-
KILLS fleas & ticks
-
PREVENTS heartworm disease
-
TREATS and controls roundworms and hookworms
IMPORTANT SAFETY INFORMATION
NexGard® PLUS (afoxolaner, moxidectin, and pyrantel chewable tablets) is safe for puppies at 8 weeks, weighing 4 pounds or more. The most frequently reported adverse reactions include diarrhea, vomiting, lethargy, and itching. Use with caution in dogs with a history of seizures or neurologic disorders. Dogs should be tested for existing heartworm infection prior to starting a preventive. For more information, click here for full prescribing information.

NexGard COMBO Topical Solution: Monthly Protection for Cats
-
KILLS fleas & ticks
-
PREVENTS heartworm disease
-
PREVENTS heartworm disease
IMPORTANT SAFETY INFORMATION
NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution) is for topical use only in cats. Safe for use in cats and kittens 8 weeks of age or older, weighing 1.8 lbs or more. Use with caution in cats with a history of seizures or neurologic disorders. The most frequently reported adverse reactions include vomiting, application site reactions, lethargy, and anorexia. If ingested, hypersalivation may occur. Avoid direct contact with application site until visibly dry. For more information, click here for full prescribing information.

NexGard Chews: Monthly Flea & Tick Protection for Dogs
-
KILLS fleas & ticks
-
PREVENTS Lyme disease infections by killing black-legged ticks
IMPORTANT SAFETY INFORMATION
NexGard® (afoxolaner) is for use in dogs only. Safe for use in puppies 8 weeks of age or older, weighing 4 pounds or more. The most frequently reported adverse reactions include vomiting, itching, lethargy, diarrhea, and lack of appetite. The safe use of NexGard in pregnant, breeding, or lactating dogs has not been evaluated. Use with caution in dogs with a history of seizures or neurologic disorders. For more information, click here for full prescribing information.

NexGard® Brand Products
When it comes to parasite protection for the dogs and cats in your home, NexGard® Brand Products have them covered. For dogs, there’s NexGard PLUS chews or NexGard chews. And for cats, there’s NexGard COMBO topical solution. Ask your vet to learn more about each of these products.
IMPORTANT SAFETY INFORMATION:
NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution) is for topical use only in cats. Safe for use in cats and kittens 8 weeks of age or older, weighing 1.8 pounds or more. Use with caution in cats with a history of seizures or neurologic disorders. The most frequently reported adverse reactions include vomiting, application site reactions, lethargy, and anorexia. If ingested, hypersalivation may occur. Avoid direct contact with application site until visibly dry. For more information, click here for full prescribing information.
NexGard® PLUS (afoxolaner, moxidectin, and pyrantel chewable tablets) is safe for puppies at 8 weeks, weighing 4 pounds or more. The most frequently reported adverse reactions include diarrhea, vomiting, lethargy, and itching. Use with caution in dogs with a history of seizures or neurologic disorders. Dogs should be tested for existing heartworm infection prior to starting a preventive. For more information, click here for full prescribing information.
NexGard® (afoxolaner) is for use in dogs only. Safe for use in puppies 8 weeks of age or older, weighing 4 pounds or more. The most frequently reported adverse reactions include vomiting, itching, lethargy, diarrhea, and lack of appetite. The safe use of NexGard in pregnant, breeding, or lactating dogs has not been evaluated. Use with caution in dogs with a history of seizures or neurologic disorders. For more information, click here for full prescribing information.