Cat Vaccinations

Vaccinating a cat is one of the most effective ways help your cat live a long and healthy life. However, it can also be a source of confusion for many owners.

Part of this confusion comes from the assumption that a cat living strictly indoors is automatically safe from infectious disease. Viruses, however, are resilient. Some can enter a home on shoes or clothing. Even the most content homebody may occasionally slip out an open door.

When you understand which vaccines a cat needs and why, the annual vet visit shifts from a stressful obligation to a calm, practical part of a wellness routine.

vet examining a cat vet examining a cat

Why Do Cats Need Vaccines?

Vaccines work by preparing the immune system to fight specific diseases. They contain antigens. These look like the disease-causing organism to the immune system but do not actually cause illness.

If a cat is exposed to the real disease later, the immune system recognizes it and fights it off effectively. This protection is vital. Many feline diseases, such as Rabies or Panleukopenia (feline distemper), can be fatal or difficult to treat once contracted.

Core vs. Lifestyle Vaccines: What Is the Difference?

Veterinary experts, such as those at the American Animal Hospital Association (AAHA), divide vaccines into two categories. These are Core and Lifestyle-based (or non-core)

  • Core Vaccines: recommended for all cats, regardless of their lifestyle. The diseases they prevent are widespread, highly contagious, or dangerous to humans.
  • Lifestyle Vaccines: recommended based on specific risk factors, such as whether a cat goes outside or lives with other cats.

Core and lifestyle vaccines may vary between kittenhood and adulthood.

When Should Cats Be Vaccinated?

Vaccination schedules depend on age and history. A typical timeline follows this pattern:

  • Kittens (6–16 weeks): Kittens receive a series of vaccinations every 3–4 weeks to build immunity as protection from their mother’s milk fades. This is also the perfect time to discuss other preventive care, such as treating fleas.
  • Adults: After the initial kitten series and a one-year booster, many adult cats can move to a schedule of every 1–3 years for core vaccines. This depends on the specific vaccine used and local regulations.

Are There Risks or Side Effects?

Modern vaccines are very safe, although mild side effects can occur. This might look like noticing your cat is extra tired, or has a reduced appetite for a day. Still, the risk of disease is still much higher than the risk of a vaccine.

Some owners are concerned about injection site reactions. To address this, many veterinarians use non-adjuvanted vaccines. These are designed to minimize inflammation at the injection site. Ask your veterinarian if this option is right for your cat.

Frequently Asked Questions

Do strictly indoor cats really need vaccines?

How much do cat vaccinations cost?

Can I vaccinate my pregnant cat?

What if I miss a scheduled booster?

Important Safety Information

NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution) is for topical use only in cats. Safe for use in cats and kittens 8 weeks of age or older, weighing 1.8 pounds or more. Use with caution in cats with a history of seizures or neurologic disorders. The most frequently reported adverse reactions include vomiting, application site reactions, lethargy, and anorexia. If ingested, hypersalivation may occur. Avoid direct contact with application site until visibly dry. For more information, click here for full prescribing information.