NEXT-LEVEL
Next-Level
Protection That's
Easy To Apply
Protects cats against:
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Fleas
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Ticks
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Roundworms
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Heartworm disease
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Hookworms
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Tapeworms
NexGard® COMBO
(esafoxolaner, eprinomectin, and praziquantel topical solution)
$50 rebate
When you buy 12 doses of NexGard COMBO topical solution from your vet, we’ll send you a $50 rebate on your purchase.* Offer expires July 31, 2026.
$20 rebate
When you buy 6 doses of NexGard COMBO topical solution from your vet, we’ll send you a $20 rebate on your purchase.* Offer expires July 31, 2026.
Convenient, Easy-to-Apply Solution
It’s no fun to pill a cat—so that’s why NexGard COMBO topical solution is designed to deliver broad-spectrum parasite protection in a topical solution that’s applied just once a month.
3 Steps to Get Protection
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Learn About NexGard® COMBO Topical Solution
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Connect With Your Vet for a Prescription
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Get Protection
Purchase Through Your Vet or Online
WHY PROTECT?
Stay Informed About
Parasite Risks
Once mature, heartworms can live up to 3 years in cats.1
Once mature, heartworms can live up to 3 years in cats.1
Fortunately, heartworm disease is preventable with the use of monthly doses of NexGard COMBO topical solution.
Heartworm disease can be transmitted by a single mosquito bite.2
Heartworm disease can be transmitted by a single mosquito bite.2
The potentially fatal disease can be transmitted to cats via infected mosquitoes and it only takes one bite. Heartworm disease is preventable with NexGard COMBO topical solution.
A flea can live up to 100 days on your cat depending on environment and food availability.3
A flea can live up to 100 days on your cat depending on environment and food availability.3
That's why it's important to protect your cat with one-and-done NexGard COMBO topical solution. Ask your vet to learn more.
Ticks are active 12 months a year.4
Ticks are active 12 months a year.4
Ask your vet about how you can protect your cat with NexGard COMBO topical solution.
SEE THE DIFFERENCE
How Does It Compare?
See how NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution) compares to other brands
| Safe for use in kittens 8 weeks of age or older, weighing 1.8lbs or more | Treats & Controls Tapeworms | Protects Against Adult Fleas | Protects Against Ticks* | Prevents Heartworm Disease | Treats & Controls Roundworm | Treats & Controls Hookworm | |
|---|---|---|---|---|---|---|---|
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| 2 species |
REVOLUTION® PLUSδ |
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| 1
| |
BRAVECTO® PLUSλ |
|
|
|
| 1
| ||
ADVANTAGE MULTI®Ω |
|
|
| 1
|
* NexGard COMBO protects against Black-legged ticks and Lone star ticks
Common Questions About NexGard COMBO
What parasites does NexGard COMBO protect against?
What parasites does NexGard COMBO protect against?
NexGard COMBO protects against fleas and ticks, prevents heartworm disease, and treats and controls roundworms, hookworms and tapeworms.
How do I apply NexGard COMBO topical solution to my cat?
How do I apply NexGard COMBO topical solution to my cat?
NexGard COMBO topical solution should be applied directly to the s kin by parting the cat’s hair on the midline of the neck between the base of the skull and the shoulder blades to minimize the possibility of the cat grooming/licking the product off.
How long does it take NexGard COMBO to work?
How long does it take NexGard COMBO to work?
Once applied to your cat’s s kin with the unique applicator, NexGard COMBO kills fleas within 24 hours of infestation and ticks.
Is NexGard COMBO safe for kittens?
Is NexGard COMBO safe for kittens?
Yes. NexGard COMBO is safe for kittens 8 weeks of age and older, weighing 1.8 lbs or more.
Learning & Resources
Browse through charts, checklists, articles and more to learn more about protection
Can My Cat Get Fleas?
Cats are just as susceptible to flea infestations as dogs, even indoor cats. It’s important to recognize the risks of fleas and understand what can be done to protect your cat. Keep reading to learn how to spot fleas on your cat and learn how a monthly protection product like NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution) can help eliminate the need to deal with fleas.
Ticks on Cats
Just like dogs, cats can get ticks. Below you will find information about ticks on your cat. You’ll also learn how monthly protection, such as NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution), plays an important role in protecting your cat from ticks.
How do Cats Get Worms?
Many pet owners are aware that cats can get parasitic worms, but they may not know what kinds of worms pose a problem for cats.
Emergency Use Authorization for NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution) for New World screwworm (NWS)
The U.S. Food and Drug Administration (FDA) has issued an Emergency Use Authorization (EUA) for the emergency use of the approved product NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution) for the treatment and prevention of infestations caused by NWS (Cochliomyia hominivorax) larvae (myiasis) in cats and kittens. NexGard® COMBO is not approved or conditionally approved for this use.
NexGard® COMBO is approved for other uses.
For additional information on the EUA, please refer to the NexGard® COMBO NWS Fact Sheet.
Limitations of Authorized Use
NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution) is authorized only for the duration of the declaration that circumstances exist justifying the authorization of the emergency use of NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution) under section 564(b)(1) of the Federal Food, Drug, and Cosmetic Act (FD&C Act), 21 U.S.C. § 360bbb-3(b)(1), unless the authorization is terminated or revoked sooner.
Do not administer orally. Cats may salivate excessively if NexGard® COMBO topical solution is accidentally administered orally or is ingested through licking/grooming the application site (see Target Animal Safety). Esafoxolaner, one of the ingredients in NexGard® COMBO, is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in cats receiving isoxazoline class drugs, even in cats without a history of seizures. Use with caution in cats with a history of seizures or neurologic disorders. The safety of NexGard® COMBO has not been tested in breeding, pregnant, or lactating cats. The safety of NexGard® COMBO has not been tested in kittens less than 8 weeks of age or weighing less than 1.8 lbs. The most frequently reported adverse reactions include vomiting, application site reactions, and anorexia.
*Available only on purchases from your veterinarian. One coupon required for every purchase. Terms and conditions apply. Must be of the same product and purchased at one time. May not be combined with any other offer. Rebate in the form of a Boehringer Ingelheim Mastercard® Prepaid Card. Please allow 6 to 8 weeks for delivery.
- Heartworm in Cats. American Heartworm Society. Accessed May 27, 2025. https://www.heartwormsociety.org/heartworms-in-cats
- Heartworm Basics. American Heartworm Society. Accessed May 27, 2025. https://www.heartwormsociety.org/pet-owner-resources/heartworm-basics
- Science Reference Section, Library of Congress. https://www.loc.gov/everyday-mysteries/zoology/item/how-long-is-the-life-span-of-a-flea/#:~:text=Without%20a%20host%20for%20food,live%20up%20to%20100%20days.
- Preventing Ticks on Pets. Centers for Disease Control and Prevention. Accessed May 26 2025. https://www.cdc.gov/ticks/prevention/preventing-ticks-on-pets.html
δ. REVOLUTION® PLUS Prescribing Information.
λ. BRAVECTO® PLUS Prescribing Information.
Ω. ADVANTAGE MULTI® Prescribing Information.
Important Safety Information
NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution) is for topical use only in cats. Safe for use in cats and kittens 8 weeks of age or older, weighing 1.8 pounds or more. Use with caution in cats with a history of seizures or neurologic disorders. The most frequently reported adverse reactions include vomiting, application site reactions, lethargy, and anorexia. If ingested, hypersalivation may occur. Avoid direct contact with application site until visibly dry. For more information, click here for full prescribing information.