FAQS
NexGard® (afoxolaner) chews
Safety
Are NexGard chews safe?
Are NexGard chews safe?
NexGard chews are both effective and safe. NexGard chews have been evaluated extensively in both laboratory clinical studies as well as in field trials in dogs. They are vet-recommended flea and tick protection for dogs, with over 300 million doses prescribed in the US.1 The most frequently reported adverse reactions include vomiting, itching, lethargy, diarrhea, and lack of appetite. Use with caution in dogs with a history of seizures or neurologic disorders
Can NexGard chews be used for cats or other animals?
Can NexGard chews be used for cats or other animals?
No, NexGard chews should only be used for dogs. Do not give NexGard chews to cats or other animals. If you want to protect your cat, check out NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution). Use with caution in cats with a history of seizures or neurologic disorders. For the full prescribing information, click here.
Are NexGard chews safe for pregnant dogs?
Are NexGard chews safe for pregnant dogs?
The safe use of NexGard chews in pregnant, breeding, or lactating dogs has not been evaluated.
Are NexGard chews safe for nursing dogs?
Are NexGard chews safe for nursing dogs?
The safe use of NexGard chews in pregnant, breeding or lactating dogs has not been evaluated.
Can NexGard chews be used with other medications?
Can NexGard chews be used with other medications?
In a well-controlled field study, NexGard chews were used with other common medications, and no adverse reactions were observed.
Can you give NexGard chews and HEARTGARD® Plus (ivermectin/pyrantel) at the same time?
Can you give NexGard chews and HEARTGARD® Plus (ivermectin/pyrantel) at the same time?
Yes, you can give NexGard chews and HEARTGARD Plus to your dog at the same time. As an alternative to giving your dog both medicines, consider giving your dog NexGard® PLUS (afoxolaner, moxidectin, and pyrantel chewable tablets) monthly for one-and-done protection against fleas, ticks, heartworm disease, hookworms and roundworms. Use NexGard PLUS with caution in dogs with a history of seizures or neurologic disorders. For more information, click here for full prescribing information.
Following the use of HEARTGARD Plus (ivermectin/pyrantel) in dogs, digestive and neurologic side effects and itching have been reported. Safe for puppies 6 weeks of age or older with no weight restrictions. All dogs should be tested for heartworm infection before starting a preventive program. For more information, click here for full prescribing information.
What is the best number to call regarding NexGard chews questions?
What is the best number to call regarding NexGard chews questions?
For any specific product questions, please call Boehringer Ingelheim Animal Health at 1-888-637-4251 or visit the Contact Us page.
Administration
How often can I give NexGard chews to my dog?
How often can I give NexGard chews to my dog?
Ensure that your dog receives a NexGard chew once a month (every 30 days) to keep your dog protected all year long.
How do I give NexGard chews to my dog?
How do I give NexGard chews to my dog?
Remove only one chew at a time from the foil-backed blister card. NexGard chews can be administered with or without food. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes to ensure that part of the dose is not lost or refused.
Is there a weight or age requirement to give my dog NexGard chews?
Is there a weight or age requirement to give my dog NexGard chews?
NexGard chews are safe for dogs and puppies as young as 8 weeks, weighing 4 pounds or more.
Can I start dosing my dog with NexGard chews at any time during the year?
Can I start dosing my dog with NexGard chews at any time during the year?
Treatment with NexGard chews may begin at any time of the year.
Do NexGard chews for dogs need to be given with food?
Do NexGard chews for dogs need to be given with food?
Unlike some treatments, NexGard chews do not need to be given with food. You can choose to give the chew to your dog any time that suits you, with or without food. For more information, click here for full prescribing information.
What do I do if my dog spits up their NexGard chew?
What do I do if my dog spits up their NexGard chew?
If it is suspected that any of the dose has been lost or if vomiting occurs following administration, re-dose with another full dose. If a dose is missed, administer NexGard chew as soon as possible and resume a monthly dosing schedule. NexGard chews may be administered with or without food.
What sizes and options are NexGard chews available in?
What sizes and options are NexGard chews available in?
NexGard chews come in packs containing 3 or 6 beef-flavored chewables, and they are available in 4 different weight sizes:
- Small (4-10 pounds)
- Medium (10.1-24 pounds)
- Large (24.1-60 pounds)
- Extra Large (60.1-121 pounds)
Can I give my dog NexGard chews early?
Can I give my dog NexGard chews early?
Most dogs will not be impacted negatively if they receive their next dose of NexGard chews early. Please consult your vet for confirmation.
What happens if you miss a month of NexGard chews dosing?
What happens if you miss a month of NexGard chews dosing?
Contact your veterinarian to discuss potential risks of infection resulting from this protection gap.
Can NexGard chews be crushed?
Can NexGard chews be crushed?
Yes. You can break up NexGard chews into smaller pieces and feed them to your dog in a small amount of food, but make sure you give your dog the whole chew within one sitting to ensure effectiveness.
What happens if I accidentally give my dog two NexGard chews?
What happens if I accidentally give my dog two NexGard chews?
If you accidentally give your dog two NexGard chews, please contact your veterinarian immediately. Neurological symptoms such as loss of balance, muscle tremors, and dilated pupils may be a sign of overdose. You can also contact animal poison control Pet Poison Helpline (855) 764-7661 or ASPCA Animal Poison Control (888) 426-4435.
General
What are NexGard chews for dogs?
What are NexGard chews for dogs?
NexGard chews are a once-monthly, delicious beef-flavored chew that provides protection against fleas and ticks. Keep up with monthly dosage to ensure year-round protection. Click here for full prescribing information.
What do NexGard chews protect against?
What do NexGard chews protect against?
NexGard chews protect against fleas and ticks. They can be used in combination with a heartworm disease prevention product like HEARTGARD Plus (ivermectin/pyrantel). NexGard chews also protect against Lyme infection as a result of killing black-legged ticks.
Following the use of HEARTGARD Plus in dogs, digestive and neurologic side effects and itching have been reported. Safe for puppies 6 weeks of age or older with no weight restrictions. All dogs should be tested for heartworm infection before starting a preventive program. For more information, click here for full prescribing information.
How do NexGard chews work?
How do NexGard chews work?
NexGard chews contain afoxolaner. Once administered, it is absorbed into the bloodstream. When fleas and ticks ingest blood containing afoxolaner, it causes hyperexcitation and kills the parasite. Afoxolaner can also help to prevent Lyme infection by killing black-legged ticks.
How long does it take for NexGard chews to kill fleas?
How long does it take for NexGard chews to kill fleas?
In a well-controlled laboratory study, afoxolaner alone began to kill fleas within 4 hours and demonstrated >99% effectiveness at 8 hours.
How long does a dose in a NexGard chew last?
How long does a dose in NexGard chews last?
NexGard chews provide monthly protection that is designed to be administered every 30 days for year-round protection. Keep up with monthly dosage using our monthly reminder tool, so you can ensure your pet is protected all year.
How long does it take for NexGard chews to work?
How long does it take for NexGard chews to work?
Afoxolaner, the active ingredient in NexGard chews, absorbs into the system within 6 hours. It is 99% effective on pre-existing flea infestations, killing them within 8 hours, and newly acquired fleas are killed within 24 hours. Ticks will die within 48-72 hours.
How do NexGard chews kill fleas?
How do NexGard chews kill fleas?
NexGard chews contains afoxolaner. Once administered, it is absorbed into the bloodstream. When fleas and ticks ingest blood containing afoxolaner, it causes hyperexcitation and kills the parasite.
How do I know if NexGard chews are working?
How do I know if NexGard chews are working?
You can tell NexGard chews are working by looking for dead fleas and ticks.
Are NexGard chews recommended for all dogs?
Are NexGard chews recommended for all dogs?
Yes—fleas are opportunists. Even if your dog only goes outside to relieve themselves, they’re at risk of infestations from fleas and ticks. Fleas can even “hitchhike” into a home on people and then jump to infest dogs. An infested pet will spread flea eggs throughout the house, which can survive in your carpet or the crannies of your wood floors and then mature to infest other animals in your home.
Can I purchase NexGard chews without a vet prescription?
Can I purchase NexGard chews without a vet prescription?
No, NexGard chews are a prescription oral chewable tablet that are indicated for the treatment and preventions of flea infestations. They are used for the treatment of five types of ticks (American dog tick, Asian longhorned tick, black-legged tick, lone star tick and brown dog tick). Consult your vet to see if NexGard chews are right for your dog.
What's the difference between NexGard chews and HEARTGARD Plus chews?
What's the difference between NexGard chews and HEARTGARD Plus chews?
NexGard (afoxolaner) chews protect against fleas and ticks, and prevents Lyme infections as a direct result of killing black-legged ticks. HEARTGARD Plus prevents heartworm disease, and treats and controls hookworms and roundworms. Consider combining both products to protect dogs from most common parasitic threats.
You can also use NexGard PLUS (afoxolaner, moxidectin and pyrantel chewable tablets) if you’d prefer an all-in-one chew to kill fleas, ticks and protect against heartworm disease, roundworms and hookworms.
Following the use of HEARTGARD Plus in dogs, digestive and neurologic side effects and itching have been reported. Safe for puppies 6 weeks of age or older with no weight restrictions. All dogs should be tested for heartworm infection before starting a preventive program. For more information, click here for full prescribing information.
Use NexGard PLUS with caution in dogs with a history of seizures or neurologic disorders. For more information, click here for full prescribing information.
What's the difference between NexGard chews and Frontline® Brand Products for dogs?
What's the difference between NexGard chews and Frontline® Brand Products for dogs?
NexGard chews require a prescription and contains afoxolaner, while FRONTLINE Brand Products can be purchased over the counter and contains fipronil and an insect growth regulator. Both NexGard chews and FRONTLINE Brand Products protect dogs from ticks and fleas.
What are the signs of fleas on dogs?
Can my dog’s fleas go away on their own?
Can my dog’s fleas go away on their own?
If your dog has fleas, they won’t go away on their own. In fact, they’ll multiply and shed flea eggs throughout the house. The developing flea stages (which include flea eggs and larvae) can survive in carpets and the cracks of wood floors for months at a time. Immature fleas in the environment will become adults, starting the cycle of infestation over.
Do NexGard chews protect dogs from Lyme infections?
Do NexGard chews protect dogs from Lyme infections?
NexGard chews are labeled to prevent Lyme infections by killing black-legged ticks.
Why does my dog still have fleas after using NexGard chews?
Why does my dog still have fleas after using NexGard chews?
You are likely seeing new fleas on your pet, which are jumping on your dog as they move through infested areas. One NexGard chew provides one month of protection, which means it will continue to kill new fleas that land on your pet before they lay eggs.
Will NexGard chews kill existing fleas?
Will NexGard chews kill existing fleas?
NexGard chews effectively kill existing fleas and prevent future infestations. However, if you have existing flea infestation before starting your dog on a flea control product, additional steps may be needed to help remove developing flea stages (eggs, larvae, and pupae) from your home.
What happens if fleas go untreated on dogs?
What happens if fleas go untreated on dogs?
If fleas go untreated, they can quickly multiply to cause an infestation. A single adult female flea can lay up to 50 eggs per day, which means that a small number of fleas can grow into the thousands.1 An infested dog will scatter flea eggs throughout their home environment, and fleas will bite other animals and humans.
What do I do if my dog is already on NexGard chews and has a tick?
What do I do if my dog is already on NexGard chews and has a tick?
If you find a tick on your dog, remove it with a tweezer or tick-removal device as soon as possible and contact your vet.
If your dog is already on NexGard chews, any new ticks will be killed within 48-72 hours. NexGard chews do not repel ticks, but instead kill them once they bite.
Can dogs get sick from ticks?
Can dogs get sick from ticks?
Yes. Ticks are carriers for several dangerous diseases. If a tick that is carrying a pathogen bites a dog, that dog is at risk of becoming infected as well.
What are the signs of ticks on dogs?
What are the signs of ticks on dogs?
Ticks can be hard to spot on dogs. Since they bite the skin, underneath your dog’s fur, it can be difficult to locate them. They also may bite hard-to-reach areas, such as under the neck or beneath the armpits. Your dog may scratch at or gnaw on tick bite locations. Ticks can also transmit various life-threatening tick-borne illnesses.
- Dryden M. Biology of fleas of dogs and cats. Compend Contin Educ Vet. 1993(4):569-579.
- Lyme Disease. Companion Animal Parasite Council. April 28, 2025. Accessed April 21, 2025. https://capcvet.org/guidelines/lyme-disease
Important Safety Information
NexGard® (afoxolaner) is for use in dogs only. Safe for use in puppies 8 weeks of age or older, weighing 4 pounds or more. The most frequently reported adverse reactions include vomiting, itching, lethargy, diarrhea, and lack of appetite. The safe use of NexGard in pregnant, breeding, or lactating dogs has not been evaluated. Use with caution in dogs with a history of seizures or neurologic disorders. For more information, click here for full prescribing information.