FAQS
NexGard® PLUS (afoxolaner, moxidectin and pyrantel chewable tablets)
Safety
Are NexGard PLUS chews safe for my dog?
Are NexGard PLUS chews safe for my dog?
NexGard PLUS chews have been evaluated extensively in both laboratory clinical studies as well as in a multi-center field trial in pet dogs. In these studies, NexGard PLUS chews were found to be well tolerated and safe for use in dogs and puppies at 8 weeks, weighing 4 lbs or more. The most frequently reported adverse reactions include vomiting, itching, lethargy, diarrhea, and lack of appetite. They are safe for use in all breeds of dogs. Use with caution in dogs with a history of seizures or neurologic disorders.
Can NexGard PLUS chews be used on cats or other animals?
Can NexGard PLUS chews be used on cats or other animals?
No. NexGard PLUS chews are for dogs only. Do not give NexGard PLUS chews to cats or other pets.
For protection for your cat, check out NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution). Use with caution in cats with a history of seizures or neurologic disorders. For the full prescribing information, click here.
Are NexGard PLUS chews safe for pregnant dogs?
Are NexGard PLUS chews safe for pregnant dogs?
The safe use of NexGard PLUS chews in pregnant, breeding, or lactating dogs has not been evaluated.
Can NexGard PLUS chews be used with other medications?
Can NexGard PLUS chews be used with other medications?
In a well-controlled field study, NexGard PLUS chews were used concurrently with other medications such as vaccines, antibiotics, non-steroidal anti inflammatory drugs (NSAIDs), anesthetics, sedatives, analgesics, steroids, anthelmintics, antiemetics, and antipruritics. No adverse reactions were associated with the concurrent use of NexGard PLUS chews and other medications.
What is the best number to call regarding NexGard PLUS chews questions?
What is the best number to call regarding NexGard PLUS chews questions?
For any specific product questions, please call Boehringer Ingelheim Animal Health at 1-888-637-4251 or visit the Contact Us page.
Administration
How do I give NexGard PLUS chews to my dog?
How do I give NexGard PLUS chews to my dog?
Remove only one chew at a time from the foil-backed blister card. NexGard PLUS chews can be administered with or without food. Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes to ensure that part of the dose is not lost or refused.
In what sizes and options are NexGard PLUS chews available in?
In what sizes and options are NexGard PLUS chews available in?
NexGard PLUS chews come in packs containing either 3 or 6 beef-flavored soft chewables, and they are available in 5 different weight sizes:
- Extra-Small (4-8 lbs)
- Small (8.1-17 lbs)
- Medium (17.1-33 lbs)
- Large (33.1-66 lbs)
- Extra-Large (66.1-132 lbs)
Do NexGard PLUS chews for dogs need to be given with food?
Do NexGard PLUS chews for dogs need to be given with food?
NexGard PLUS chews do not need to be given with food and can be administered any time that suits you. See product label for full details and directions for use.
Can I start treating my dog with NexGard PLUS chews at any time during the year?
Can I start treating my dog with NexGard PLUS chews at any time during the year?
Treatment with NexGard PLUS chews may begin at any time of the year. Dogs should be tested for existing heartworm infection prior to starting NexGard PLUS chews.
Can I cut NexGard PLUS chews in half?
Can I cut NexGard PLUS chews in half?
The chew can be broken into smaller pieces and be fed to your dog in small amount of food. Ensure the entire dose is readily consumed for full effectiveness. Do not store chews from opened blisters.
Can NexGard PLUS chews be crushed?
Can NexGard PLUS chews be crushed?
The chew can be broken into smaller pieces and be fed to your dog in small amount of food. Ensure the entire dose is readily consumed for full effectiveness. Do not store chews from opened blisters.
What do I do if my dog spits up their NexGard PLUS chew?
What do I do if my dog spits up their NexGard PLUS chew?
If it is suspected that any of the dose has been lost or if vomiting occurs within 2 hours of administration, re-dose with another full dose. If a dose is missed, administer a NexGard PLUS chew as soon as possible and resume a monthly dosing schedule. NexGard PLUS chews may be administered with or without food.
General
What are NexGard PLUS chews for dogs?
What are NexGard PLUS chews for dogs?
NexGard PLUS chews are a once monthly, delicious beef-flavored chew that provides protection against fleas, ticks, heartworm disease, roundworms and hookworms. Keep up with monthly dosage to ensure year-round protection. See product label for full details and directions for use.
What do NexGard PLUS chews protect against?
What do NexGard PLUS chews protect against?
NexGard PLUS chews protect against fleas and ticks, prevents heartworm disease, and treats and control roundworms and hookworms.
How do NexGard PLUS chews work?
How do NexGard PLUS chews work?
NexGard PLUS chews contain 3 active ingredients: afoxolaner kills fleas and ticks, moxidectin prevents heartworm disease, and pyrantel treats and controls roundworms and hookworms.
How long does it take for NexGard PLUS chews to work?
How long does it take for NexGard PLUS chews to work?
One of the active ingredients in NexGard PLUS chews (afoxolaner) absorbs into the system within 6 hours. In a controlled study, they were found to be 99% effective on pre-existing flea infestations, killing them within 8 hours, and newly acquired fleas are killed within 24 hours. NexGard PLUS chews kill black-legged ticks within 48 hours.
How long does a dose of NexGard PLUS chews last and how often should I treat my dog?
How long does a dose of NexGard PLUS chews last and how often should I treat my dog?
NexGard PLUS chews provide powerful protection against fleas and ticks for a full month. Each monthly chew works to prevent heartworm disease by killing any heartworm larvae that were acquired in the previous month. It’s important to ensure that your dog receives a monthly NexGard PLUS chew year-round to keep your dog protected against fleas, ticks, and heartworm disease.
How do I know if NexGard PLUS chews are working?
How do I know if NexGard PLUS chews are working?
You can tell NexGard PLUS chews are working by looking for dead fleas and ticks, and by noting if your dog’s scratching decreases.
What company manufactures NexGard PLUS chews?
What company manufactures NexGard PLUS chews?
NexGard® (afoxolaner) chews and NexGard PLUS chews are manufactured by Boehringer Ingelheim.
Use NexGard chews with caution in dogs with a history of seizures or neurologic disorders. For more information, click here for full prescribing information.
Does my dog need a prescription for NexGard PLUS chews?
Does my dog need a prescription for NexGard PLUS chews?
Your dog will need an annual negative heartworm test and a prescription for NexGard PLUS chews from your veterinarian.
How long does it take for NexGard PLUS chews to kill fleas?
How long does it take for NexGard PLUS chews to kill fleas?
In a well-controlled laboratory study, afoxolaner alone began to kill fleas within 4 hours and demonstrated >99% effectiveness at 8 hours.
How do NexGard PLUS chews kill fleas?
How do NexGard PLUS chews kill fleas?
NexGard PLUS chews contains afoxolaner. Once administered, it is absorbed into the bloodstream. When fleas and ticks ingest blood containing afoxolaner, it causes hyperexcitation and kills the parasite.
Will NexGard PLUS chews kill existing fleas?
Will NexGard PLUS chews kill existing fleas?
NexGard PLUS chews effectively kill existing fleas and prevents future infestations by killing fleas before they lay eggs. However, if you have an existing flea infestation before starting your dog on a flea control product, additional steps may be needed to help remove developing flea stages (eggs, larvae, and pupae) from your home, which can continue to hatch and cause an infestation for months.
Why am I still seeing fleas on my dog after using NexGard PLUS chews?
Why am I still seeing fleas on my dog after using NexGard PLUS chews?
You are likely seeing NEW fleas on your pet, which are jumping on your dog as they move through infested areas. These fleas will be killed quickly by NexGard PLUS chews before they can reproduce. Depending on the severity of an already existing infestation as well as environmental conditions, you may continue to see new fleas jumping on your pet for 3 months or more. To prevent new infestations, continue to give NexGard PLUS chews consistently each month throughout the year.
What are signs of fleas in dogs?
What are signs of fleas in dogs?
Fleas can cause itchy, painful skin conditions on your dog. Signs of fleas include scratching or biting at the skin, hair loss, scabs, and irritation.
What happens if fleas go untreated in dogs?
What happens if fleas go untreated in dogs?
If fleas go untreated, they can quickly multiply to cause an infestation. A single adult female flea can lay up to 50 eggs per day, which means that a small number of fleas can grow into the thousands.1 An infested dog will scatter flea eggs throughout their home environment, and fleas will bite other animals, including humans.
How long does it take for NexGard PLUS chews to kill ticks?
How long does it take for NexGard PLUS chews to kill ticks?
In well-controlled laboratory studies, afoxolaner alone demonstrated >97% effectiveness against Dermacentor variabilis (American dog tick), >94% effectiveness against Ixodes scapularis (black-legged tick), and >93% effectiveness against Rhipicephalus sanguineus (brown dog tick) 48 hours post-infestation for 1 month.
Can my dog still get ticks with NexGard PLUS chews?
Can my dog still get ticks with NexGard PLUS chews?
NexGard PLUS chews do not prevent ticks from getting on your dog or the ticks from attaching. They do, however, kill them rapidly within 48 hours of attachment.
What are the signs of ticks on dogs?
What are the signs of ticks on dogs?
Ticks can be hard to spot on dogs. Since they bite the skin, underneath your dog’s fur, it can be difficult to locate them. They also may bite hard-to-reach areas, such as under the neck or beneath the armpits. Your dog may scratch at or gnaw on tick bite locations. Ticks can also transmit various life-threatening tick-borne illnesses.
Can dogs get sick from ticks?
Can dogs get sick from ticks?
Yes. Ticks are carriers for several dangerous diseases. If a tick that is carrying a pathogen bites a dog, that dog is at risk of becoming infected as well.
How do NexGard PLUS chews kill worms in dogs?
How do NexGard PLUS chews kill worms in dogs?
NexGard PLUS chews have moxidectin in it, which prevents heartworm disease before they mature into adults. It also has pyrantel, which treats and controls roundworms and hookworms.
Do NexGard PLUS chews protect against heartworm disease?
Do NexGard PLUS chews protect against heartworm disease?
Yes. NexGard PLUS chews prevent heartworm disease by killing heartworm larvae before they mature into adults. NexGard PLUS chews are also effective at killing fleas, ticks and controlling hookworms and roundworms with convenient monthly one-and-done protection.
What is heartworm disease?
What is heartworm disease?
Heartworm disease is a serious and potentially fatal disease in dogs and cats. It is transmitted to pets via mosquitoes, and even a single bite of infected mosquito poses risk of heartworm disease. Adult heartworms live in blood vessels of lungs, and in severe cases heart, causing irreversible damage.1
How do dogs get heartworm disease?
How do dogs get heartworm disease?
Dogs get heartworms from infected mosquitoes. Heartworm larvae enter the dog through the mosquito bite and over time develop into adult heartworms, which cause heartworm disease. One bite is all it takes.2
How can I reduce the risk of heartworm disease in my dog?
How can I reduce the risk of heartworm disease in my dog?
There are 3 things you can do to help reduce the risk of heartworm disease:
- Use heartworm disease preventives, like monthly NexGard PLUS chews, on a year-round basis to prevent heartworm larvae from growing into dangerous adult heartworms.4
- Reduce mosquito exposure by eliminating standing water where mosquitoes can breed, avoid known mosquito habitats, and limit outdoor exposure during peak mosquito feeding times.2
- Get your dog tested every year. Before getting a prescription for a heartworm disease preventive, your dog should be tested for heartworms. Talk to your vet about testing options.2
Is there an effective natural prevention for heartworm disease?
Is there an effective natural prevention for heartworm disease?
Because heartworm disease is passed on from the bite of an infected mosquito, there is no natural prevention for your pet. Talk to your veterinarian about the different heartworm disease preventive medications available for your pet.
Can heartworm disease be treated?
Can heartworm disease be treated?
Yes, it can be treated, but heartworm disease is a serious condition that can cause heart failure, permanent damage to your pet’s lungs, and even death.4 Treating heartworm disease is costly and complicated.5
- Dryden M. Biology of fleas of dogs and cats. Compend Contin Educ Vet. 1993(4):569-579.
- Current Canine Guidelines for the Prevention, Diagnosis, and Management of Heartworm Infections in Dogs. American Heartworm Society. 2020. Accessed April 28, 2025. https://www.heartwormsociety.org/images/pdf/AHS_Canine_Guidelines_11_13_20.pdf
- Heartworm Basics. American Heartworm Society. Accessed April 28, 2025. https://www.heartwormsociety.org/pet-owner-resources/heartworm-basics
- Lynn RC, Duquette RA. Chapter 6. Antiparasitic Drugs. In: Bowman DD, ed. Georgis’ Parasitology for Veterinarians. 11th ed. St. Louis, MO: Elsevier; 2021: 286-348.
- Weigh the Costs Infographic. American Heartworm Society. Accessed April 28, 2025. https://d3ft8sckhnqim2.cloudfront.net/images/infographics/0010-weigh-the-costs.jpg
Important Safety Information
NexGard® PLUS (afoxolaner, moxidectin, and pyrantel chewable tablets) is safe for puppies at 8 weeks, weighing 4 pounds or more. The most frequently reported adverse reactions include diarrhea, vomiting, lethargy, and itching. Use with caution in dogs with a history of seizures or neurologic disorders. Dogs should be tested for existing heartworm infection prior to starting a preventive. For more information, click here for full prescribing information.