FAQS

NexGard® PLUS (afoxolaner, moxidectin and pyrantel chewable tablets)

Safety

Are NexGard PLUS chews safe for my dog?

Are NexGard PLUS chews safe for pregnant dogs?

Can NexGard PLUS chews be used with other medications?

What is the best number to call regarding NexGard PLUS chews questions?

Administration

How do I give NexGard PLUS chews to my dog?

In what sizes and options are NexGard PLUS chews available in?

Do NexGard PLUS chews for dogs need to be given with food?

Can I start treating my dog with NexGard PLUS chews at any time during the year?

Can I cut NexGard PLUS chews in half?

Can NexGard PLUS chews be crushed?

What do I do if my dog spits up their NexGard PLUS chew?

General

What are NexGard PLUS chews for dogs?

What do NexGard PLUS chews protect against?

How do NexGard PLUS chews work?

How long does it take for NexGard PLUS chews to work?

How long does a dose of NexGard PLUS chews last and how often should I treat my dog?

How do I know if NexGard PLUS chews are working?

What company manufactures NexGard PLUS chews?

Does my dog need a prescription for NexGard PLUS chews?

How long does it take for NexGard PLUS chews to kill fleas?

How do NexGard PLUS chews kill fleas?

Will NexGard PLUS chews kill existing fleas?

Why am I still seeing fleas on my dog after using NexGard PLUS chews?

What are signs of fleas in dogs?

What happens if fleas go untreated in dogs?

How long does it take for NexGard PLUS chews to kill ticks? 

Can my dog still get ticks with NexGard PLUS chews? 

What are the signs of ticks on dogs?

Can dogs get sick from ticks?

How do NexGard PLUS chews kill worms in dogs?

Do NexGard PLUS chews protect against heartworm disease? 

What is heartworm disease?

How do dogs get heartworm disease?

How can I reduce the risk of heartworm disease in my dog?

Is there an effective natural prevention for heartworm disease?

Can heartworm disease be treated?

OFFERS & REBATES

Enjoy special savings when you protect your pet.

  1. Dryden M. Biology of fleas of dogs and cats. Compend Contin Educ Vet. 1993(4):569-579.
  2. Current Canine Guidelines for the Prevention, Diagnosis, and Management of Heartworm Infections in Dogs. American Heartworm Society. 2020. Accessed April 28, 2025. https://www.heartwormsociety.org/images/pdf/AHS_Canine_Guidelines_11_13_20.pdf
  3. Heartworm Basics. American Heartworm Society. Accessed April 28, 2025. https://www.heartwormsociety.org/pet-owner-resources/heartworm-basics
  4. Lynn RC, Duquette RA. Chapter 6. Antiparasitic Drugs. In: Bowman DD, ed. Georgis’ Parasitology for Veterinarians. 11th ed. St. Louis, MO: Elsevier; 2021: 286-348.
  5. Weigh the Costs Infographic. American Heartworm Society. Accessed April 28, 2025. https://d3ft8sckhnqim2.cloudfront.net/images/infographics/0010-weigh-the-costs.jpg

Important Safety Information

NexGard® PLUS (afoxolaner, moxidectin, and pyrantel chewable tablets) is safe for puppies at 8 weeks, weighing 4 pounds or more. The most frequently reported adverse reactions include diarrhea, vomiting, lethargy, and itching. Use with caution in dogs with a history of seizures or neurologic disorders. Dogs should be tested for existing heartworm infection prior to starting a preventive. For more information, click here for full prescribing information.