Proven, Next-Level Monthly Protection
One-and-Done Monthly.
A Low-Risk Switch.
Try out NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution) and see the difference with our one-and-done monthly topical solution that comes with an award-winning applicator.
Protection against:
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Fleas
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Ticks
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Heartworm disease
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Roundworms
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Hookworms
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Tapeworms
SEE THE DIFFERENCE
Compare NexGard COMBO topical solution to other brands
Safe for use in | Treats & | Protects Against Adult Fleas | Protects Against Ticks* | Prevents Heartworm Disease | Treats & Controls Roundworms | Treats & Controls Hookworms | |
 |  | | | | | | 2 species |
REVOLUTION® PLUSδ |  | | | | | 1 | |
BRAVECTO® PLUSλ | | | | | 1 species | ||
ADVANTAGE MULTI®Ω | | | | 1 species |
*NexGard COMBO protects against black-legged ticks and Lone star ticks
$20 rebate
When you buy 6 doses of NexGard COMBO topical solution from your vet, we’ll send you a $20 rebate on your purchase.* Offer expires July 31, 2026.
$50 rebate
When you buy 12 doses of NexGard COMBO topical solution from your vet, we’ll send you a $50 rebate on your purchase.* Offer expires July 31, 2026.
3 Steps To Get Protection
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Choose Your NexGard Brand Product
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Get a Prescription From Your Vet
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Purchase Through Your Vet or Online
δ. REVOLUTION® PLUS Prescribing Information.
λ. BRAVECTO® PLUS Prescribing Information.
Ω. ADVANTAGE MULTI® Prescribing Information.
Important Safety Information
NexGard® PLUS (afoxolaner, moxidectin, and pyrantel chewable tablets) is safe for puppies at 8 weeks, weighing 4 pounds or more. The most frequently reported adverse reactions include diarrhea, vomiting, lethargy, and itching. Use with caution in dogs with a history of seizures or neurologic disorders. Dogs should be tested for existing heartworm infection prior to starting a preventive. For more information, click here for full prescribing information.
NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution) is for topical use only in cats. Safe for use in cats and kittens 8 weeks of age or older, weighing 1.8 pounds or more. Use with caution in cats with a history of seizures or neurologic disorders. The most frequently reported adverse reactions include vomiting, application site reactions, lethargy, and anorexia. If ingested, hypersalivation may occur. Avoid direct contact with application site until visibly dry. For more information, click here for full prescribing information.
NexGard® (afoxolaner) is for use in dogs only. Safe for use in puppies 8 weeks of age or older, weighing 4 pounds or more. The most frequently reported adverse reactions include vomiting, itching, lethargy, diarrhea, and lack of appetite. The safe use of NexGard in pregnant, breeding, or lactating dogs has not been evaluated. Use with caution in dogs with a history of seizures or neurologic disorders. For more information, click here for full prescribing information.