Next-Level Protection For Your Dog or Cat
Proven, One-and-Done Monthly Protection
Here are some great options for passionate pet owners looking for highly effective, one-and-done monthly solutions.
Protection against:
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Fleas
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Ticks
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Heartworm disease
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Roundworms
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Hookworms
Protection against:
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Fleas
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Ticks
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Heartworm disease
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Roundworms
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Hookworms
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Tapeworms
WHY PROTECT?
Stay Informed About Parasite Risks
Once mature, heartworms can live up to 3 years in cats.1
Once mature, heartworms can live up to 3 years in cats.1
Fortunately, heartworm disease is preventable with the use of monthly doses of NexGard COMBO topical solution.
Ticks are active 12 months a year.2
Ticks are active 12 months a year.2
Tick populations drop only 20% in the winter. Protect your pet with NexGard PLUS Chews. Contact your vet to help you select the right dosage.
A flea can lay up to 3000 eggs in its lifetime and can live up to 100 days on your pet.3
A flea can lay up to 3000 eggs in its lifetime and can live up to 100 days on your pet.3
NexGard PLUS can help you prevent flea infestation with a one-and-done monthly chew.
1.2 million dogs in the US are estimated to have heartworm disease.4
1.2 million dogs in the US are estimated to have heartworm disease.4
Ask your vet about how you can protect your dog with NexGard PLUS monthly chews.
SEE THE DIFFERENCE
How Does it Compare?
NexGard PLUS vs. NexGard Chews
NexGard PLUS vs. NexGard Chews
Prevents heartworm disease | Treats & controls roundworms and hookworms | Kills | Kills | Same efficacy with or without food | Approved for dogs and puppies as young as 8 weeks | Prevents Lyme infections* | |
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* Prevents Lyme infections as a direct result of killing black-legged ticks
NexGard PLUS vs. Simparica Trio®
NexGard PLUS vs. Simparica Trio®
Tasty beef-flavored chew Preferred by dogs*Φ | Treats & controls 3 species of hookworms | Kills | Kill 6 types | Prevents heartworm disease | Treats & | Same efficacy with or | Prevents | |
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SIMPARICA TRIO®β | 2 |  | | | | | |
* In a study, for dogs that demonstrated a preference, they preferred NexGard® PLUS chews over SIMPARICA TRIO®.
** As a direct result of killing black-legged ticks.
NexGard PLUS vs. Bravecto
NexGard PLUS vs. Bravecto
Prevents heartworm disease | Same efficacy with or without food | Treats and controls hookworms and roundworms | Prevents Lyme infections* | Kills | Approved for dogs and puppies as young as 8 weeks, weighing 4lbs or more | Tasty beef-flavored chew | Kills | |
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| BRAVECTO®ψ |
| Kills 5 types of ticks Lone Star Tick for 8 weeks only. | 6+ months, weighing 4.4 lbs or more | Pork-flavored chew |  |
* As a direct result of killing black-legged ticks.
NexGard PLUS vs. Credelio Quattro®
NexGard PLUS vs. Credelio Quattro®
Can be | Treats & | Kills 6 types | Kills | Prevents | Prevents | Treats and | |
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| CREDELIO QUATTRO®Σ | 2 | Kills 5 types |  | | | |
* As a direct result of killing black-legged ticks.
NEXGARD® PLUS & NEXGARD® COMBO
Have you given your cat NexGard® COMBO? Have you given your dog NexGard® PLUS? Tell us what you think.
3 Steps To Get Protection
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Choose Your NexGard Brand Product
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Get a Prescription From Your Vet
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Purchase Through Your Vet or Online
- Heartworm in Cats. American Heartworm Society. Accessed March 1, 2023. https://www.heartwormsociety.org/heartworms-in-cats
- Preventing Tick Bites. Centers for Disease Control and Prevention. Accessed February 25 2022. https://www.cdc.gov/ticks/prevention/index.html
- News, PVM. 2022. “Indiana Media Outlet Turns to PVM’s Dr. Paulo Gomes for Advice for Pet Owners about Fleas.” College of Veterinary Medicine. July 22, 2022. https://vet.purdue.edu/news/indiana-media-outlet-turns-to-pvms-dr-paulo-gomes-for-advice-for-pet-owners-about-fleas.php.
- Heartworm incidence climbs despite preventive efforts. American Veterinary Medical Association. Published October 8, 2025. https://www.avma.org/news/heartworm-incidence-climbs-despite-preventive-efforts
β. SIMPARICA TRIO® Prescribing Information
Φ. Data on file at Boehringer Ingelheim.
ψ. BRAVECTO® Prescribing Information
Σ. CREDELIO QUATTRO® Prescribing Information
Important Safety Information
NexGard® PLUS (afoxolaner, moxidectin, and pyrantel chewable tablets) is safe for puppies at 8 weeks, weighing 4 pounds or more. The most frequently reported adverse reactions include diarrhea, vomiting, lethargy, and itching. Use with caution in dogs with a history of seizures or neurologic disorders. Dogs should be tested for existing heartworm infection prior to starting a preventive. For more information, click here for full prescribing information.
NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution) is for topical use only in cats. Safe for use in cats and kittens 8 weeks of age or older, weighing 1.8 pounds or more. Use with caution in cats with a history of seizures or neurologic disorders. The most frequently reported adverse reactions include vomiting, application site reactions, lethargy, and anorexia. If ingested, hypersalivation may occur. Avoid direct contact with application site until visibly dry. For more information, click here for full prescribing information.