Next-Level Protection For Next-Level Cat Lovers
Proven, One-and-Done Monthly Protection
NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution) is the one-and-done monthly topical solution that’s highly effective and comes with an award-winning applicator, making it easy to use.
Protection against:
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Fleas
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Ticks
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Heartworm disease
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Roundworms
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Hookworms
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Tapeworms
Why protect?
Stay Informed About Parasite Risks
Heartworms can live in cats for up to 3 years. Even one can be life-threatening.1
Once mature, heartworms can live up to 3 years in cats.1
Fortunately, heartworm disease is preventable with the use of monthly doses of NexGard COMBO topical solution.
Heartworm disease can be transmitted by a single mosquito bite and is often fatal in cats.2
Heartworm disease can be transmitted by a single mosquito bite.2
The potentially fatal disease can be transmitted to cats via infected mosquitoes and it only takes one bite. Heartworm disease is preventable with NexGard COMBO topical solution.
A flea can live up to 100 days on your cat depending on environment and food availability.3
A flea can live up to 100 days on your cat depending on environment and food availability.3
That's why it's important to protect your cat with one-and-done NexGard COMBO topical solution. Ask your vet to learn more.
Ticks are active 12 months a year.4
Ticks are active 12 months a year.4
Ask your vet about how you can protect your cat with NexGard COMBO topical solution.
SEE THE DIFFERENCE
Compare NexGard COMBO topical solution to other brands
Safe for use in | Treats & | Protects Against Adult Fleas | Protects Against Ticks* | Prevents Heartworm Disease | Treats & Controls Roundworms | Treats & Controls Hookworms | |
 |  | | | | | | 2 species |
REVOLUTION® PLUSδ |  | | | | | 1 | |
BRAVECTO® PLUSλ | | | | | 1 species | ||
ADVANTAGE MULTI®Ω | | | | 1 species |
*NexGard COMBO protects against black-legged ticks and Lone star ticks
3 Steps To Get Protection
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Choose Your NexGard Brand Product
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Get a Prescription From Your Vet
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Purchase Through Your Vet or Online
- Heartworm in Cats. American Heartworm Society. Accessed March 1, 2023. https://www.heartwormsociety.org/heartworms-in-cats
- Heartworm Basics. American Heartworm Society. Accessed May 27, 2025. https://www.heartwormsociety.org/pet-owner-resources/heartworm-basics
- Science Reference Section, Library of Congress https://www.loc.gov/everyday-mysteries/zoology/item/how-long-is-the-life-span-of-a-flea/#:~:text=Without%20a%20host%20for%20food,live%20up%20to%20100%20days.
- Preventing Tick Bites. Centers for Disease Control and Prevention. Accessed February 25 2022. https://www.cdc.gov/ticks/prevention/index.html
δ. REVOLUTION® PLUS Prescribing Information.
λ. BRAVECTO® PLUS Prescribing Information.
Ω. ADVANTAGE MULTI® Prescribing Information.
Important Safety Information
NexGard® COMBO (esafoxolaner, eprinomectin, and praziquantel topical solution) is for topical use only in cats. Safe for use in cats and kittens 8 weeks of age or older, weighing 1.8 pounds or more. Use with caution in cats with a history of seizures or neurologic disorders. The most frequently reported adverse reactions include vomiting, application site reactions, lethargy, and anorexia. If ingested, hypersalivation may occur. Avoid direct contact with application site until visibly dry. For more information, click here for full prescribing information.